Clonotype Analysis of Cytomegalovirus-Specific Cytotoxic T Lymphocytes

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Clonotype analysis of cytomegalovirus-specific cytotoxic T lymphocytes.

Cytotoxic T lymphocytes (CTL) control the replication of human cytomegalovirus (CMV). Previous studies assessed the clonotypic composition of CTL specific for individual immunodominant peptides within a certain HLA context. Such an approach has inherent limitations and may not assess the true clonal CTL response in vivo. Here, the clonotypic composition of CMV-specific CTL was determined in HLA...

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ژورنال

عنوان ژورنال: Journal of the American Society of Nephrology

سال: 2008

ISSN: 1046-6673,1533-3450

DOI: 10.1681/asn.2007111225